Specific diacylglycerols generated by hepatic lipogenesis stimulate the oncogenic androgen receptor activity in male hepatocytes.

Ya-Wen ChengKai-Wei ChenHan-Chun KuoChing-Hua KuoWei-Hsiang LinPei-Jer ChenShiou-Hwei Yeh

Published in: International journal of obesity (2005) (2019)

Our study elucidates a novel mechanism underlying the higher risk of HCC in obese/NAFLD males, through specific DAGs enriched by hepatic lipogenesis to increase the transcriptional activity of hepatic AR, a confirmed risk factor for male HCC.

Keyphrases

transcription factor
metabolic syndrome
adipose tissue
gene expression
oxidative stress