Condition Screening for Sustainable Catalysis in Single-Electron Steps by Cyclic Voltammetry: Additives and Solvents.

Cyclic voltammetry-based screening method for Cp2 TiX-catalyzed reactions is extended to the screening of solvents other than tetrahydrofuran for bulk electrolysis of the catalyst and radical arylation. It was found that CH3 CN can be used as a solvent for both processes without additives. Furthermore, in tetrahydrofuran, squaramide L2 is more efficient than the previously reported supramolecular halide binder, Schreiner's thiourea L1. The results extend the usefulness of the proposed time and resource-efficient screening method for designing catalysis reactions in single-electron steps.