Integrative Bioinformatics Analysis Revealed Mitochondrial Dysfunction-Related Genes Underlying Intervertebral Disc Degeneration.

Zhengya Zhu Zhongyuan He Tao TangFuan WangHongkun ChenBaoliang LiGuoliang Chen Jianmin WangWei TianDafu ChenXinbao WuXizhe Liu Zhiyu ZhouShaoyu Liu

Published in: Oxidative medicine and cellular longevity (2022)

We identified four genes (SOX9, FLVCR1, NR5A1 and UCHL1) associated with mitochondrial dysfunction that play an important role in the progress of disc degeneration. The identification of these differential genes may provide new insights for the diagnosis and treatment of IDD.

Keyphrases

bioinformatics analysis
stem cells
transcription factor
single cell