Characterisation of nerve-mediated ATP release from bladder detrusor muscle and its pathological implications.

Carly J McCarthyYouko IkedaDeborah SkennertonBasu ChakrabartyAnthony J KanaiRita I JabrChristopher Henry Fry

Published in: British journal of pharmacology (2019)

Atropine resistance in nerve-mediated detrusor contractions is due to ATP release and its magnitude is inversely related to E-NTPDase-1 activity. ATP is released under different stimulation conditions compared with ACh, implying different routes for their release.

Keyphrases

botulinum toxin
peripheral nerve
spinal cord injury
skeletal muscle
drug induced