CD8+ T cells inhibit metastasis and CXCL4 regulates its function.
Robiya JosephRama SoundararajanSuhas VasaikarFei YangKendra L AlltonLin TianPetra den HollanderSevinj IsgandarovaMonika HaemmerleBarbara MinoTieling ZhouCrystal ShinMelisa Martinez-PaniaguaAysegul A SahinJaime Rodriguez-CanalesJuri GelovaniJeffrey T ChangGhanashyam AcharyaAnil K SoodIgnacio I WistubaDon L GibbonsLuisa M SolisMichelle C BartonNavin VaradarajanJeffrey M RosenXiang H ZhangSandurai A ManiPublished in: British journal of cancer (2021)
CD8+ T cells inhibit metastasis. When the balance between CD8+ T cells and platelets is disrupted, platelets produce CXCL4, which induces MDSCs thereby inhibiting the CD8+ T-cell function.