How to evaluate potential non-specific effects of vaccines: the quest for randomized trials or time for triangulation?

Christine Stabell BennAne Bærent FiskerAndreas RieckmannAksel Karl Georg JensenPeter Aaby

Published in: Expert review of vaccines (2018)

Using RCTs alone to evaluate NSEs of vaccines severely limits the possibilities for studying NSEs. Results from both RCTs and non-RCT studies should be triangulated to strengthen causal interpretation.

Keyphrases

case control
human health
risk assessment