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Highly Thiolated Dendritic Mesoporous Silica Nanoparticles with High-Content Gold as Nanozymes: The Nano-Gold Size Matters.

Mohammad KalantariTrisha GhoshYang LiuJun ZhangJin ZouChang LeiChengzhong Yu
Published in: ACS applied materials & interfaces (2019)
Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g-1) are synthesized and used to load gold nanoparticles with tunable sizes (1.2-2.7 nm) and high content (34.0 wt %). It is demonstrated that the size of gold nanoparticles has a significant impact on their peroxidase-mimicking activity. At an optimized size of 1.9 nm, T-DMSNs@Au exhibits the highest activity. Our contribution provides new insights into the rational design of nanozymes for future applications.
Keyphrases
  • gold nanoparticles
  • reduced graphene oxide
  • photodynamic therapy
  • hydrogen peroxide
  • light emitting
  • nitric oxide