Increased circulating level of interleukin-6 and CD8+ T cell exhaustion are associated with progression of COVID-19.

Peng-Hui YangYi-Bo DingZhe XuRui PuPing LiJin YanJi-Luo LiuFan-Ping MengLei HuangLei ShiTian-Jun JiangEn-Qiang QinMin ZhaoDa-Wei ZhangPeng ZhaoLing-Xiang YuZhao-Hai WangZhi-Xian HongZhao-Hui XiaoQing XiDe-Xi ZhaoPeng YuCai-Zhong ZhuZhu ChenShao-Geng ZhangJun-Sheng JiFu-Sheng WangGuang-Wen Cao

Published in: Infectious diseases of poverty (2020)

Older age and higher levels of C-reactive protein, procalcitionin, interleukin-6, and lactate might predict COVID-19 progression. T lymphocyte, especially CD8+ cell-mediated immunity is critical in recovery of COVID-19. This study may help in predicting disease progression and designing immunotherapy for COVID-19.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
single cell
mesenchymal stem cells
cell therapy
peripheral blood