Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration.
Magdalena PatrycyMarcin ChodkowskiMałgorzata KrzyżowskaPublished in: Pathogens (Basel, Switzerland) (2022)
Neuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue. Upon viral infection of the CNS, microglia become activated and start to produce inflammatory mediators important for clearance of the virus, but an excessive neuroinflammation can harm nearby neuronal cells. Herpesviruses express several molecular mechanisms, which can modulate apoptosis of infected neurons, astrocytes and microglia but also divert immune response initiated by the infected cells. In this review we also describe the link between virus-related neuroinflammation, and development of neurodegenerative diseases.
Keyphrases
- inflammatory response
- cell cycle arrest
- lipopolysaccharide induced
- cerebral ischemia
- lps induced
- induced apoptosis
- traumatic brain injury
- oxidative stress
- neuropathic pain
- immune response
- blood brain barrier
- cognitive impairment
- endoplasmic reticulum stress
- pi k akt
- spinal cord
- subarachnoid hemorrhage
- signaling pathway
- brain injury
- patient safety
- dendritic cells
- physical activity
- cell proliferation
- weight gain