Acute Toxoplasma gondii infection alters the number of neurons and the proportion of enteric glial cells in the duodenum in Wistar rats.
Aline Rosa TrevizanLarissa Carla Lauer SchneiderEduardo José de Almeida AraújoJoão Luis GarciaNilza Cristina ButtowGessilda de Alcântara Nogueira-MeloDébora de Mello Gonçales Sant AnaPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
We found decrease of neurons and increase in the EGC/neuron ratio in both plexuses caused by acute T. gondii infection, with major alterations 72 hours after oral infection. The number of cholinergic neurons decreased in the submucosal plexus, and the number of nitrergic neurons decreased in the myenteric plexus. A decrease in the number of enteric glial cells was observed in the submucosal plexus, and an increase in the enteric glial cell/neuron ratio was observed in both ganglionate plexuses of the duodenum.