Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays.
Maziar ShabestariYashar R ShabestariMaria A LandinMilaim PepajTimothy P ClelandJanne Elin ReselandErik Fink EriksenPublished in: International journal of rheumatic diseases (2020)
Reduced osteoprotegerin, ACAN and HAPL1 are consistent with osteoclastic activation and high remodeling activity in BMLs. The pronounced increase in angiogenesis markers, hemoglobin and serum albumin support the presence of increased vascularity in subchondral bone affected by BMLs in OA. VEGFs and IL-6 are known nociceptive modulators, and increased levels are in keeping with pain being a clinical feature frequently associated with BMLs.
Keyphrases
- bone marrow
- neuropathic pain
- chronic pain
- knee osteoarthritis
- small molecule
- machine learning
- mass spectrometry
- mesenchymal stem cells
- endothelial cells
- rheumatoid arthritis
- bone mineral density
- pain management
- high throughput
- vascular endothelial growth factor
- nuclear factor
- protein protein
- soft tissue
- spinal cord
- total hip arthroplasty
- amino acid
- real time pcr
- postmenopausal women
- neural network
- bone regeneration