Biomarkers of joint metabolism and bone mineral density are associated with early knee osteoarthritis in premenopausal females.
Nan HuJing ZhangJing WangPei WangJing WangYongqian QiangZicheng LiTianming WuXing WangYahong WangJiao LiXiaoping LiuJirong ZhangXiuyuan FengBomiao JuZhiming HaoDan PuXiaohong LuQiang WangLan HePublished in: Clinical rheumatology (2021)
The joint metabolism biomarkers and BMD showed multiple associations with early knee OA in premenopausal females, but not in males aged before 50 years. It was suggested that sex differences should be taken into account when evaluating cartilage and bone metabolism in early knee OA. Key Points • The joint metabolism biomarkers and BMD are associated with early knee OA in premenopausal females, but not in males aged before 50 years. • Sex differences should be taken into account when evaluating cartilage and bone metabolism in early knee OA.