Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis.
Li GaoJie-Xing QinJian-Quan ShiTeng JiangFei WangChong XieQing GaoNan ZhiQing DongYang-Tai GuanPublished in: CNS neuroscience & therapeutics (2022)
These results suggested that PM2.5 exposure triggered the activation of NLRP3 inflammasome and pyroptosis under ischemic conditions, which may be mediated by increased ROS production after ischemic stroke. These findings may provide a more enhanced understanding of the interplay between PM2.5 and neuroinflammation and cell death, and reveal a novel mechanism of PM2.5-mediated toxic effects after ischemic stroke.
Keyphrases
- nlrp inflammasome
- particulate matter
- air pollution
- cell death
- cerebral ischemia
- atrial fibrillation
- ischemia reperfusion injury
- traumatic brain injury
- dna damage
- genome wide
- lipopolysaccharide induced
- single cell
- reactive oxygen species
- brain injury
- signaling pathway
- subarachnoid hemorrhage
- dna methylation
- inflammatory response
- oxidative stress