Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.

Dong-Dong WuZhengguo LiuJianmei LiQianqian ZhangPeiyu ZhongTieshan TengMingliang ChenZhongwen XieAiling JiYanzhang Li

Published in: Cancer cell international (2019)

EGCG could reduce the growth and increase the apoptosis of human thyroid carcinoma cells through suppressing the EGFR/RAS/RAF/MEK/ERK signaling pathway. EGCG can be developed as an effective therapeutic agent for the treatment of thyroid cancer.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
induced apoptosis
endothelial cells
small cell lung cancer
cell proliferation
epithelial mesenchymal transition
epidermal growth factor receptor
endoplasmic reticulum stress
tyrosine kinase
induced pluripotent stem cells
oxidative stress
smoking cessation