Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer's disease.

Wei-Ming SuXiao-Jing GuMeng DouQing-Qing DuanZheng JiangKang-Fu YinWei-Chen CaiBei CaoYi WangYong-Ping Chen

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

This study provides genetic evidence supporting the potential therapeutic benefits of targeting the three druggable genes for AD treatment, which will be useful for prioritising AD drug development.

Keyphrases

genome wide
dna methylation
copy number
gene expression
cancer therapy
replacement therapy