Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.

Xin WangDanxiu LiLina SunGaofei ShenHao LiuHao GuoMinghui GeJunrong LiangPing ChenJinchi ZhouTianyu CaoQi WangXiaoliang GaoMingfu TongSijun HuYongzhan NieDaiming FanXin WangXiao-Di ZhaoYuanyuan Lu

Published in: British journal of cancer (2020)

Our study demonstrates the oncogenic roles and underlying mechanisms of Ran in CRC and the novel miR-802/Ran/EGFR regulatory axis may provide potential biomarkers for the treatment of CRC.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
transcription factor
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
combination therapy
replacement therapy