The novel GLP-1/GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD.

Cheng LiWeizhen LiuXiaohui LiZijuan ZhangHuaxin QiShijin LiuNingning YanYing XingChristian HolscherZhiju Wang

Published in: Brain and behavior (2020)

Therefore, our results demonstrate that DA5-CH has neuroprotective effects in the STZ-induced animal model and that DA5-CH has potential to treat neurodegenerative disorders such as AD.

Keyphrases

diabetic rats
room temperature
oxidative stress
high glucose
working memory
atrial fibrillation
transcranial magnetic stimulation
heart rate
cerebrospinal fluid
drug induced
prefrontal cortex
climate change
human health