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Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents.

Danah S Al-ShamaryMonirah A Al-AlshaikhNabila Abdelshafy KhederYahia Nasser MabkhotSyed Lal Badshah
Published in: Chemistry Central journal (2017)
The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs.
Keyphrases
  • molecular docking
  • molecular dynamics simulations
  • oxidative stress
  • anti inflammatory
  • climate change
  • human health
  • structure activity relationship