Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin-induced myocardial injury.

Qingling Zhang Yunpeng ZhangBingxin XieDaiqi LiuYueying WangZandong ZhouYue ZhangEmma KingGary TseTong Liu

Published in: Cancer innovation (2023)

Doxorubicin toxicity leads to abnormal mitochondrial morphology and dysfunction in cardiomyocytes and induces apoptosis by interfering with mitochondrial fusion. Resveratrol ameliorates doxorubicin-induced cardiotoxicity by activating SIRT1/MFN2 to improve mitochondria function.

Keyphrases

oxidative stress
diabetic rats
high glucose
drug delivery
cancer therapy
ischemia reperfusion injury
cell death
endothelial cells
signaling pathway