Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity.

Ting-I KaoPo-Jen ChenYi-Hsuan WangHsin-Hui TsengShih-Hsin ChangTian-Shung WuSien-Hung YangYen-Tung LeeTsong-Long Hwang

Published in: British journal of pharmacology (2021)

Bletinib regulates neutrophilic inflammation by inhibiting the SFK-Btk-Vav pathway. Bletinib ameliorates LPS-induced ALI in mice. Further biochemical optimisation of bletinib may be a promising strategy for the development of novel therapeutic agents for inflammatory diseases.

Keyphrases

lps induced
oxidative stress
tyrosine kinase
inflammatory response
signaling pathway
protein kinase
mouse model
high fat diet induced
adipose tissue