HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression.
Dong WuTingting ChenXuanna ZhaoDan HuangJiawei HuangYujie HuangQiu HuangZhu LiangChunyuan ChenMin ChenDongming LiBin WuLixia LiPublished in: Journal of experimental & clinical cancer research : CR (2022)
Our results revealed that the circ-0001875/miR-31-5p/SP1 axis and the complex regulatory loops influence NSCLC progression. These findings provide new insights into the regulation of circRNA formation under tumor hypoxia.