COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.
Katerina L ByanovaRebecca A AbelmanCrystal M NorthStephanie A ChristensonLaurence HuangPublished in: International journal of chronic obstructive pulmonary disease (2023)
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of COPD and an earlier and more rapid decline in lung function than their seronegative counterparts, even after accounting for differences in cigarette smoking. Factors contributing to this HIV-associated difference include chronic immune activation and inflammation, accelerated aging, a predilection for pulmonary infections, alterations in the lung microbiome, and the interplay between HIV and inhalational toxins. In this review, we discuss what is known about the epidemiology and pathobiology of COPD among PWH and outline screening, diagnostic, prevention, and treatment strategies.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- cystic fibrosis
- hepatitis c virus
- air pollution
- hiv aids
- men who have sex with men
- risk factors
- oxidative stress
- multiple sclerosis
- south africa
- pulmonary hypertension
- physical activity
- depressive symptoms