Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation.
Ying-Wei LanWan-Ru ChenGary Ro-Lin ChangYing-Cheng ChenKowit-Yu ChongKai-Cheng ChuangYung-Tsung KaoMing-Shan ChenChuan-Mu ChenPublished in: Cell & bioscience (2024)
This loss-of-function study suggests that AKR1A1 plays a liver-protective role during chronic alcohol consumption by reducing the accumulation of 4-HNE and inhibiting 4-HNE-mediated p53 activation.
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