Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling.

Nils LudwigSaigopalakrishna S YerneniJuliana H AzambujaDelbert G GillespieElizabeth V MenshikovaEdwin K JacksonTheresa L Whiteside

Published in: Angiogenesis (2020)

This report provides the first evidence for adenosine production by TEX to promote angiogenesis via A2BR. A2BR antagonism emerges as a potential strategy to block TEX-induced angiogenesis.

Keyphrases

endothelial cells
vascular endothelial growth factor
high glucose
wound healing
mesenchymal stem cells
stem cells
diabetic rats
oxidative stress
bone marrow