Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice.

Xiaoyi Zheng Lauren E HigdonAlexandre GaudetManav ShahAngela BalistieriCatherine LiPatricia de Nadai Latha PalaniappanXiaoping YangBriana SantoBrandon GinleyXiaoxin X WangKomuraiah MyakalaPratima NallagatlaMoshe LeviPinaki SarderAvi Z Rosenberg Jonathan S MaltzmanNathalie de Freitas CairesVivek Bhalla

Published in: Kidney360 (2022)

We demonstrate that, in DKD-susceptible mice, Esm-1 protects against diabetes-induced albuminuria and podocytopathy, possibly through select IFN signaling. Companion studies in patients with diabetes suggest a role of Esm-1 in human DKD.

Keyphrases

endothelial cells
high glucose
type diabetes
cardiovascular disease
diabetic rats
immune response
vascular endothelial growth factor
dendritic cells
high fat diet induced
glycemic control
case control
drug induced
insulin resistance
oxidative stress
weight loss