The Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells.

Reinhard DeppingMoritz von FalloisYosef LandesmanFriederike Katharina Kosyna

Published in: OncoTargets and therapy (2019)

Here, we demonstrate the effect of specific XPO1-inhibition on the hypoxic response on the molecular level in 2D and 3D culture models of MCF-7 cells.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
pi k akt
endoplasmic reticulum stress
oxidative stress
cell death