β-Arrestin1 is involved in hepatocellular carcinoma metastasis via extracellular signal-regulated kinase-mediated epithelial-mesenchymal transition.

Xuan Xu Yiming Lei Haoxiong Zhou Yun-Wei Guo Huiling Liu Jie Jiang Yidong Yang Bin Wu

Published in: Journal of gastroenterology and hepatology (2020)

Our data suggest that ARRB1 promotes HCC invasion and metastasis through p-ERK1/2-mediated EMT and that suppression of ARRB1 or p-ERK1/2 may offer potential therapeutic targets for HCC therapy.

Keyphrases

epithelial mesenchymal transition
signaling pathway
pi k akt
cell proliferation
transforming growth factor
electronic health record
transcription factor
cell therapy
smoking cessation