Synaptic Loss in Spinocerebellar Ataxia Type 3 Revealed by SV2A Positron Emission Tomography.

Zhao ChenGuang LiaoNa WanZhiyou HeDaji ChenZhichao TangZhe LongGuangdong ZouLinliu PengLinlin WanChunrong WangHuirong PengYuting ShiYongxiang TangJian LiYulai LiTingting LongXuan HouLang HeRong QiuDengming ChenJun-Ling Wang Ji-Feng Guo Lu ShenYiyun HuangTetsuo AshizawaThomas KlockgetherBei-Sha TangMing ZhouShuo HuJiang Hong

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

We first identified in vivo synaptic loss was related to disease severity of SCA3, suggesting SV2A PET could be a promising clinical biomarker for disease progression of SCA3. © 2023 International Parkinson and Movement Disorder Society.

Keyphrases

positron emission tomography
computed tomography
pet ct
pet imaging
prefrontal cortex
early onset