Chemical constituents from Solanum nigrum and their neuroprotective activities.

Ming BaiQian ZhangZi-Lin HouChuan LiWei-Yu ZhouGuo-Dong YaoXiao-Xiao Huang Shao-Jiang Song

Published in: Journal of Asian natural products research (2021)

Ten compounds (1-10) including four new compounds (1-4) and six known compounds (5-10) were isolated from Solanum nigrum. Their structures were elucidated on the basis of spectroscopic data, gauge-including atomic orbital (GIAO) calculation of NMR data, DP4+ probability analysis and comparison of their experimental and calculated electronic circular dichroism (ECD) spectral data. All the isolated compounds were tested for their neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 5 and 7 displayed moderate neuroprotective effects.

Keyphrases

electronic health record
big data
high resolution
induced apoptosis
oxidative stress
magnetic resonance
magnetic resonance imaging
computed tomography
high intensity
machine learning
endothelial cells
blood brain barrier
cerebral ischemia
high glucose
endoplasmic reticulum stress
solid state
monte carlo