Pretreatment and Acquired Antiretroviral Drug Resistance Among Persons Living With HIV in Four African Countries.
Trevor A CrowellBrook DanboiseAjay ParikhAllahna EsberNicole DearPeter CoakleyAlex KasembeliJonah MaswaiSamoel KhamadiEmmanuel BahemanaMichael IroezinduFrancis KiweewaJohn OwuothJoanna FreemanLinda L JagodzinskiJennifer A MaliaLeigh Ann EllerSodsai TovanabutraSheila A PeelJulie A AkeChristina S Polyaknull nullPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Participants on failing ART regimens had a high burden of HIVDR that potentially limited the efficacy of standardized first- and second-line regimens. Management strategies that emphasize adherence counseling while delaying ART switch may promote drug resistance and should be reconsidered.