Evaluation of the short term host response and biomechanics of an absorbable poly-4-hydroxybutyrate scaffold in a sheep model following vaginal implantation.
Chantal M DiedrichZeliha GulerLucie HympanovaEva V VodegelManuel ZündelEdoardo MazzaJan A DeprestJan Paul RooversPublished in: BJOG : an international journal of obstetrics and gynaecology (2021)
P4HB scaffold facilitated a gradual load transfer to vaginal tissue over time. The fully absorbable P4HB scaffold, in comparison to PP mesh, has a favorable host response with comparable load-bearing capacity. If these results are also observed at longer follow-up in-vivo, a clinical study using P4HB for vaginal POP surgery may be warranted to demonstrate efficacy.