Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer.

April LoMaria McSharryAlice H Berger

Published in: BMC cancer (2022)

Proteomic and transcriptomic profiling of lung epithelial cells uncovered splicing factor phosphorylation and mRNA splicing events regulated by oncogenic KRAS. These data suggest that in addition to widespread transcriptional changes, the Ras signaling pathway can promote post-transcriptional splicing changes that may contribute to oncogenic processes.

Keyphrases

transcription factor
wild type
signaling pathway
gene expression
single cell
protein kinase
electronic health record
heat shock
cell proliferation
binding protein
artificial intelligence
label free
heat stress