Elevated plasma interleukin-8 as a risk factor for mortality in children presenting with cerebral malaria.
Jade RoyoBertin VianouManfred AccrombessiElisée KinkpéLinda AyédadjouIda Dossou-DagbaYélé LadipoMaroufou Jules AlaoGwladys I BertinMichel CotFarid BoumédièneSandrine HouzéJean François FaucherAgnès Aubouynull nullPublished in: Infectious diseases of poverty (2023)
The main risk factor of death during CM was thus elevated plasma levels of IL-8 at inclusion. Follow-up of patients until D30 revealed marker profiles of disease aggravation and resolution for markers implicated in neutrophil activation, endothelium activation and damage, inflammatory and oxidative response. These results provide important insight into our understanding of CM pathogenesis and clinical outcome and may have important therapeutic implications.
Keyphrases
- risk factors
- end stage renal disease
- ejection fraction
- oxidative stress
- newly diagnosed
- nitric oxide
- young adults
- prognostic factors
- subarachnoid hemorrhage
- peritoneal dialysis
- cardiovascular disease
- single molecule
- case report
- patient reported outcomes
- brain injury
- blood brain barrier
- patient reported
- cerebral blood flow