An Experience of Donor Lymphocyte Infusion after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease.
Tahereh RostamiAzadeh KiumarsiPublished in: Pediatric reports (2020)
Allogeneic hematopoietic stem-cell transplantation is a well-known curative treatment for patients with chronic granulomatous disease. We present our experiment regarding ten patients with chronic granulomatous disease who underwent a reduced intensity conditioning regimen consisting of melfalan, fludarabine, and antithymocyte globulin. Donor lymphocyte infusion was used in three representative patients who developed mixed donor chimerism. After at least 2 years of median follow-up, 8 of the 10 patients are alive and well.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- acute lymphoblastic leukemia
- end stage renal disease
- low dose
- interstitial lung disease
- prognostic factors
- newly diagnosed
- chronic kidney disease
- ejection fraction
- high intensity
- rheumatoid arthritis
- peripheral blood
- systemic sclerosis
- peritoneal dialysis