Risk of congenital heart defects in offspring exposed to maternal diabetes mellitus: an updated systematic review and meta-analysis.

Letao ChenTubao YangLizhang ChenLesan WangTingting WangLijuan ZhaoZiwei YeSenmao ZhangLiu LuoZan ZhengJiabi Qin

Published in: Archives of gynecology and obstetrics (2019)

The maternal DM including PGDM and GDM are significantly associated with risk of CHDs and its most phenotypes. The PGDM seems to be more likely to cause CHDs in offspring than GDM. Further studies are needed to clarify the underlying mechanisms.

Keyphrases

high fat diet
birth weight
pregnancy outcomes
glycemic control
type diabetes
adipose tissue
metabolic syndrome