Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice.

Kenichi IshizawaQin WangJinping LiNing XuYoshikazu NemotoChikayuki MorimotoWataru FujiiYoshifuru TamuraYoshihide FujigakiKazuhisa TsukamotoToshiro FujitaShunya UchidaShigeru Shibata

Published in: Journal of the American Society of Nephrology : JASN (2019)

Dysregulation of KLHL3 is involved in the pathophysiology of type 2 diabetes. These data offer a rationale for use of thiazide in individuals with diabetes and provide insights into the mechanism for cardiorenal protective effects of SGLT2 inhibitors.

Keyphrases

type diabetes
cardiovascular disease
adipose tissue
weight loss
electronic health record
metabolic syndrome
glycemic control
big data
clinical trial
bariatric surgery
skeletal muscle
insulin resistance