Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling.

Charles McWherterYun-Jung ChoiRamon L SerranoSushil K MahataRobert TerkeltaubRu Liu-Bryan

Published in: Arthritis research & therapy (2018)

Arhalofenate acid is anti-inflammatory and acts via AMPK activation and its downstream signaling in macrophages. These effects likely contribute to a reduction of gout flares.

Keyphrases

protein kinase
anti inflammatory
skeletal muscle
high glucose
uric acid
drug induced
metabolic syndrome