Association of intraneural perineurioma with neurofibromatosis type 2.
Courtney PendletonRobert J SpinnerP James B DyckMichelle L MauermannAdil LadakCarlos E RestrepoSaurabh BahetiChristopher J KleinPublished in: Acta neurochirurgica (2020)
The rarity of both NF2 and perineuriomas could explain the rarity of perineuriomas in the setting of NF2. Furthermore, there is divergent intraneural and soft tissue perineurioma somatic mutation pathogenesis, and there may be cytogenetic overlap between perineuriomas and multiple tumor syndromes. Our observed occurrence of intraneural perineurioma in the setting of NF2 in several patients provides further evidence of a potential link between the NF2 gene and the development of intraneural perineurioma.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- nuclear factor
- oxidative stress
- end stage renal disease
- soft tissue
- ejection fraction
- newly diagnosed
- copy number
- chronic kidney disease
- risk assessment
- peritoneal dialysis
- genome wide
- cell proliferation
- toll like receptor
- dna methylation
- immune response
- climate change
- patient reported outcomes
- patient reported
- genome wide identification