Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress.
José Luis Guerrero-OrriachMaria Dolores Carmona-LuqueLaura Gonzalez-AlvarezPublished in: International journal of molecular sciences (2022)
Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) compared to intravenous hypnotics (propofol). We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs' effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs.
Keyphrases
- heart failure
- oxidative stress
- diabetic rats
- clinical trial
- cardiac surgery
- end stage renal disease
- left ventricular
- ischemia reperfusion injury
- ejection fraction
- chronic kidney disease
- dna damage
- drug induced
- newly diagnosed
- peritoneal dialysis
- acute kidney injury
- prognostic factors
- atrial fibrillation
- pulmonary hypertension
- induced apoptosis
- acute heart failure
- low dose
- signaling pathway
- nitric oxide
- patient reported outcomes
- open label
- copy number
- lower limb
- heat shock protein