[Efficacy of Mexidol in combination with cerebral revascularization in the treatment of ischemic stroke].
A M AlasheevE V LantsovaPublished in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2024)
Stroke is an acute life-threatening condition; its outcome is determined by the degree of damage to brain tissue, the quality and speed of medical care in the first minutes and hours after its occurrence. The main mechanism of brain tissue damage during both ischemia and reperfusion is oxidative stress. The review covers adverse influence oxidative stress at the cerebral ischemia and reperfusion periodes of ischemic stroke. The results of preclinical studies demonstrating the ability of Mexidol to neutralize the effects of free radicals and activate antioxidant protection are presented. Data from clinical studies of the use of Mexidol in combination with thrombolysis in patients with ischemic stroke are reviewed.
Keyphrases
- cerebral ischemia
- oxidative stress
- subarachnoid hemorrhage
- atrial fibrillation
- brain injury
- blood brain barrier
- ischemia reperfusion injury
- dna damage
- diabetic rats
- induced apoptosis
- pulmonary embolism
- liver failure
- risk assessment
- percutaneous coronary intervention
- white matter
- stem cells
- big data
- heart failure
- acute coronary syndrome
- multiple sclerosis
- coronary artery bypass grafting
- case control
- heat shock
- respiratory failure
- cell therapy
- extracorporeal membrane oxygenation
- deep learning
- smoking cessation
- resting state
- endoplasmic reticulum stress