Effects of Gasdermin D in Modulating Murine Lupus and its Associated Organ Damage.

Xinghao WangLuz P BlancoCarmelo Carmona-RiveraShuichiro NakaboHege L PedersenZu-Xi YuMariana J Kaplan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

GSDMD negatively regulates autoantigen generation and immune dysregulation in response to tissue injury and may play previously unappreciated protective roles in systemic autoimmunity.

Keyphrases

systemic lupus erythematosus
disease activity
oxidative stress
signaling pathway
rheumatoid arthritis
celiac disease
drug induced