PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.

Imran NooraniJorge de la RosaYoon Ha ChoiAlexander StrongHannes PonstinglM S VijayabaskarJusung LeeEunmin LeeAngela Richard-LondtMathias FriedrichFederica FurlanettoRocio FuenteRuby BanerjeeFengtang YangFrances LawColin WattsRoland RadGeorge VassiliouJong Kyoung KimThomas SantariusSebastian BrandnerAllan Bradley

Published in: Genome biology (2020)

Our work elucidates functional driver landscapes of EGFR-mutant gliomas, uncovering potential therapeutic strategies, and provides new tools for functional interrogation of gliomagenesis.

Keyphrases

small cell lung cancer
high grade
epidermal growth factor receptor
tyrosine kinase
copy number
human health
genome wide
single cell
risk assessment
climate change