Elevated circulating BMP9 aggravates pulmonary angiogenesis in hepatopulmonary syndrome rats through ALK1-Endoglin-Smad1/5/9 signalling.

Chunyong YangMei SunYihui YangYan HanXiulin WuXianfeng WuHuilin CaoLin ChenYuhao LeiXiaoyan HuYang ChenZiyang ZengJunhong LiXin ShuZhiyong YangKaizhi LuYujie LiXiaobo WangBin Yi

Published in: European journal of clinical investigation (2024)

This study provided evidence that elevated circulating BMP9, secreted from the liver, promote pulmonary angiogenesis in HPS rats via ALK1-Endoglin-Smad1/5/9 pathway. In addition, BMP9-regulated pathways are also involved in accumulation of pro-angiogenic monocytes in the pulmonary microvasculature in HPS rats.

Keyphrases

pulmonary hypertension
mesenchymal stem cells
epithelial mesenchymal transition
endothelial cells
transforming growth factor
bone regeneration
vascular endothelial growth factor
advanced non small cell lung cancer
dendritic cells
transcription factor