MEIS transcription factors in development and disease.

Published in: Development (Cambridge, England) (2019)

MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.

Keyphrases

transcription factor
gene expression
stem cells
genome wide identification
genome wide
dna methylation
papillary thyroid
dna binding
bioinformatics analysis
squamous cell
pregnant women
genome wide analysis
bone marrow
cell therapy
lymph node metastasis