The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland.
Unnur StyrkársdóttirSigrun H LundSaedis SaevarsdottirMagnus I MagnussonKristbjorg GunnarsdottirGudmundur L NorddahlMichael L FriggeErna V IvarsdottirGyda BjornsdottirHilma HolmGudmundur ThorgeirssonThorunn RafnarIngileif JonsdottirThorvaldur IngvarssonHelgi JonssonPatrick SulemUnnur ThorsteinsdottirDaniel GudbjartssonKári StefánssonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Through a hypothesis-free approach, we identified CRTAC1 in plasma as a novel promising candidate biomarker for OA that is both associated with occurrence of OA and predictive of progression to joint replacement. This biomarker might also be useful in the selection of suitable patients for clinical trial enrollment.
Keyphrases
- clinical trial
- end stage renal disease
- knee osteoarthritis
- newly diagnosed
- ejection fraction
- computed tomography
- risk assessment
- chronic kidney disease
- mass spectrometry
- peritoneal dialysis
- magnetic resonance imaging
- magnetic resonance
- health insurance
- patient reported outcomes
- open label
- amino acid
- protein protein
- patient reported
- affordable care act
- dual energy
- binding protein
- placebo controlled