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Improvement in Lung Function and Patient-Reported Outcomes in Patients with COPD with Comorbid Anxiety and Depression Receiving Nebulized Glycopyrrolate in the GOLDEN 3 and 4 Studies.

Nicola A HananiaAbebaw Mengistu YohannesAyca Ozol-GodfreyMichael ToccoThomas GoodinSanjay SharmaShahin Sanjar
Published in: International journal of chronic obstructive pulmonary disease (2021)
GLY 25 µg BID resulted in numerical improvements in FEV1, SGRQ total scores and SGRQ responder rates in patients with moderate-to-very-severe COPD, regardless of A/D status at baseline; significant improvements were noted only in the A/D (+) group. The results emphasize the importance of considering underlying comorbidities including A/D when evaluating the efficacy of COPD treatments.
Keyphrases
  • lung function
  • chronic obstructive pulmonary disease
  • patient reported outcomes
  • cystic fibrosis
  • air pollution
  • early onset
  • high intensity
  • case control