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Internet-Based Germline Genetic Testing for Men With Metastatic Prostate Cancer.

Heather H ChengAlexandra O SokolovaRoman GulatiDeborah BowenSarah A KnerrNola KlemfussPetros D GrivasAndrew C HsiehJohn K LeeMichael T SchweizerTodd YezefskiAlicia Y ZhouEvan Y YuPeter S NelsonR Bruce Montgomery
Published in: JCO precision oncology (2023)
Here, we show the feasibility of delivering germline (inherited) genetic testing by a voluntary, patient-driven, Internet-based platform to men with mPC. Preliminary results show rates of germline DNA repair mutations, consistent with other cohorts. Although feasible for some, reduced steps for participation, more dedicated diverse outreach and participant support, and identification and addressing of additional barriers is needed to ensure equitable access and optimization.
Keyphrases
  • dna repair
  • prostate cancer
  • dna damage
  • dna damage response
  • health information
  • middle aged
  • squamous cell carcinoma
  • small cell lung cancer
  • radical prostatectomy
  • physical activity
  • single cell