The relationship between simulated milrinone exposure and hypotension in children.

Sarah Jane CommanderDaniel GonzalezKaran R KumarTracy SpearsMichael Cohen-WolkowiezKanecia O ZimmermanStephen J BalevicChristoph P Hornik

Published in: Cardiology in the young (2021)

We successfully leveraged a population pharmacokinetic model and electronic health record data to evaluate the relationship between simulated plasma concentration of milrinone and systemic hypotension occurrence, respectively, supporting the broader applicability of our novel, efficient, and cost-effective study design for examining drug exposure-response and -safety relationships.

Keyphrases

electronic health record
adverse drug
clinical decision support
young adults
risk assessment
emergency department
drug induced
machine learning
deep learning