Synergistic Anticancer Potential of Artemisinin When Loaded with 8-Hydroxyquinoline-Surface Complexed-Zinc Ferrite Magnetofluorescent Nanoparticles and Albumin Composite.
Uday Narayan PanPallab SanpuiAnumita PaulArun ChattopadhyayPublished in: ACS applied bio materials (2018)
Herein, we report the fabrication of a novel class of magnetofluorescent theranostic nanoparticles (MFTNPs) based on "surface-complexation" of zinc ferrite (ZnFe 2 O 4 ) NPs with 8-hydroxyquinoline. The potential of these MFTNPs in fluorescence-based bioimaging of different cancer cells was successfully demonstrated. The superparamagnetic behavior of the MFTNPs was exploited effectively in magnetic targeting in vitro . Finally, a well-known hydrophobic antimalarial and prospective anticancer drug artemisinin was efficiently loaded into MFTNPs. Artemisinin loaded MFTNPs were observed to induce superior antiproliferative response, as compared to free drug, in cancer cells in a synergistic mechanism with combination index of 0.1 or less.
Keyphrases
- cancer therapy
- plasmodium falciparum
- drug delivery
- oxide nanoparticles
- wound healing
- iron oxide
- quantum dots
- photodynamic therapy
- human health
- adverse drug
- single molecule
- iron oxide nanoparticles
- emergency department
- living cells
- molecularly imprinted
- walled carbon nanotubes
- risk assessment
- drug induced
- climate change
- electronic health record