Therapeutic Drug Monitoring and Prolonged Infusions of Ceftolozane/Tazobactam for MDR/XDR Pseudomonas aeruginosa Infections: An Observational Study.

María Eugenia Navarrete-RoucoSonia LuqueLuisa SorlíAdela Benítez-CanoJason A RobertsSantiago Grau

Published in: European journal of drug metabolism and pharmacokinetics (2022)

The administration of C/T by prolonged infusion with TDM-guided dosing allowed the achievement of a pharmacokinetic/pharmacodynamic target even at lower doses. C/T showed a high efficacy for treating MDR/XDR P. aeruginosa infections.

Keyphrases

multidrug resistant
drug resistant
gram negative
pseudomonas aeruginosa
acinetobacter baumannii
cystic fibrosis
low dose
biofilm formation
escherichia coli